全文获取类型
收费全文 | 32397篇 |
免费 | 2079篇 |
国内免费 | 259篇 |
专业分类
耳鼻咽喉 | 434篇 |
儿科学 | 591篇 |
妇产科学 | 489篇 |
基础医学 | 3986篇 |
口腔科学 | 1544篇 |
临床医学 | 2664篇 |
内科学 | 8680篇 |
皮肤病学 | 391篇 |
神经病学 | 3301篇 |
特种医学 | 1315篇 |
外科学 | 5229篇 |
综合类 | 93篇 |
一般理论 | 6篇 |
预防医学 | 1312篇 |
眼科学 | 538篇 |
药学 | 1695篇 |
中国医学 | 72篇 |
肿瘤学 | 2395篇 |
出版年
2023年 | 333篇 |
2022年 | 275篇 |
2021年 | 1095篇 |
2020年 | 745篇 |
2019年 | 1022篇 |
2018年 | 1205篇 |
2017年 | 956篇 |
2016年 | 1067篇 |
2015年 | 1130篇 |
2014年 | 1459篇 |
2013年 | 1779篇 |
2012年 | 2780篇 |
2011年 | 2678篇 |
2010年 | 1499篇 |
2009年 | 1370篇 |
2008年 | 2145篇 |
2007年 | 2256篇 |
2006年 | 2031篇 |
2005年 | 1844篇 |
2004年 | 1643篇 |
2003年 | 1495篇 |
2002年 | 1295篇 |
2001年 | 256篇 |
2000年 | 233篇 |
1999年 | 220篇 |
1998年 | 192篇 |
1997年 | 170篇 |
1996年 | 125篇 |
1995年 | 136篇 |
1994年 | 123篇 |
1993年 | 105篇 |
1992年 | 114篇 |
1991年 | 93篇 |
1990年 | 79篇 |
1989年 | 54篇 |
1988年 | 85篇 |
1987年 | 61篇 |
1986年 | 44篇 |
1985年 | 63篇 |
1984年 | 52篇 |
1983年 | 43篇 |
1982年 | 43篇 |
1981年 | 28篇 |
1980年 | 24篇 |
1979年 | 41篇 |
1978年 | 30篇 |
1977年 | 22篇 |
1974年 | 21篇 |
1973年 | 31篇 |
1972年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
71.
72.
Marco Del Chiaro Caroline Verbeke 《World journal of gastrointestinal pathophysiology》2015,6(2):29-32
Pancreatic cystic neoplasms(PCNs) are a high prevalence disease. It is estimated that about 20% of the general population is affected by PCNs. Some of those lesions can progress till cancer, while others behave in a benign fashion. In particular intraductal papillary mucinousneoplasms of the pancreas can be considered as the pancreatic analogon to colonic polyps. Treatment of these precursor lesions at an early stage can potentially reduce pancreas cancer mortality and introduce a new "era" of preemptive pancreatic surgery. However, only few of those lesions have an aggressive behavior. The accuracy of preoperative diagnosis, i.e., the distinction between the various PCNs is around 60%, and the ability to predict the future outcome is also less accurate. For this reason, a significant number of patients are currently over-treated with an unnecessary, high-risk surgery. Furthermore, the majority of patients with PCN are on life-long follow-up with imaging modality, which has huge cost implications for the Health Care System for limited benefits considering that a significant proportion of PCNs are or behave like benign lesions. The current guidelines for the diagnosis and management of PCNs are more based on expert opinion than on evidence. For all those reasons, the management of cystic tumors of the pancreas remains a controversial area of pancreatology. On one hand, the detection of PCNs and the surgical treatment of pre-cancerous neoplasms can be considered a big opportunity to reduce pancreatic cancer related mortality. On the other hand, PCNs are associated with a considerable risk of under- or over- treatment of patients and incur high costs for the Health Care System. 相似文献
73.
74.
Wojciech Szychta M.D. Ph.D. Gheorghe Cerin M.D. Ph.D. F.E.S.C. Bogdan Adrian Popa M.D. Armienti Felice M.D. Guido Lanzillo M.D. Ph.D. Marco Diena M.D. Grzegorz Opolski M.D. Ph.D. F.E.S.C. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1040-1043
Sinus venosus atrial septal defect (SV‐ASD) usually coexists with partial anomalous pulmonary vein connection (PAPVC). It is a difficult diagnosis in transthoracic echocardiography (TTE) due to eccentric position of defects. We present a rare case of atypical anatomical variation in PAPVC, which was never described before. Two right pulmonary veins drained into superior vena cava, which overrode SV‐ASD and interatrial septum, a third pulmonary vein into the right atrium. Complete diagnosis could not be set after TTE, nor transesophageal echocardiography, whereas angio‐CT was finally conclusive. This diagnostic approach allowed the surgical planning. 相似文献
75.
76.
77.
Francesco Pierantoni Umberto Basso Marco Maruzzo Evelina Lamberti Davide Bimbatti Giuseppina Tierno Eleonora Bergo Antonella Brunello Vittorina Zagonel 《Journal of Geriatric Oncology》2021,12(2):290-297
BackgroundThere is poor data on the prognostic role of Comprehensive Geriatric Assessment (CGA) in older patients with metastatic renal cell carcinoma (mRCC) treated with first line Tyrosine Kinase Inhibitors (TKIs).Materials and MethodsWe retrospectively reviewed the clinical charts of mRCC patients older than 70 years treated at our Institute with first-line Sunitinib or Pazopanib for at least 6 months. Every patient received a CGA at baseline and was identified as fit, vulnerable or frail according to Balducci's Criteria. We then assessed the impact of CGA category on survival, disease control and tolerability of TKIs.ResultsWe identified 86 eligible patients. Median age: 74.5 years, 56% males; 45.4% were fit, 37.2% vulnerable and 17.4% frail at CGA. There were no significant differences in the rate of Grade (G)1–2 and G3-4 toxicities, dose reduction rates, PFS and OS between Sunitinib and Pazopanib. Fit, vulnerable and frail patients achieved significantly different median PFS (18.9 vs 11.2 vs 5.1 months; p < 0.001) and OS (35.5 vs 14.6 vs 10.9 months; p < 0.001). Patients categorized as fit had higher chance of receiving a second-line treatment (66.6% vs 28.9% in vulnerable/frail; p = 0.002). The incidence of G3/4 events was significantly lower in the fit subgroup (19% vs 45% in vulnerable/frail; p = 0.0025).ConclusionsIn our retrospective single-center experience, CGA could accurately discriminate patients with higher risk of experiencing G3/4 toxicities, shorter PFS, and lower chance of receiving a second line treatment. CGA strongly impacted on OS, independently from International mRCC Database Consortium (IMDC) classification. 相似文献
78.
79.
Simona Coco Simona Boccardo Marco Mora Vincenzo Fontana Irene Vanni Carlo Genova Angela Alama Sandra Salvi Maria Giovanna Dal Bello Silvia Bonfiglio Erika Rijavec Claudio Sini Giulia Barletta Federica Biello Franca Carli Zita Cavalieri Giovanni Burrafato Luca Longo Francesco Grossi 《Clinical breast cancer》2021,21(3):218-230.e6
IntroductionBreast cancer survivors are at increased risk of developing unrelated primary cancers, particularly lung cancer. Evidence indicates that sex hormones as well as a deregulation of DNA-repair pathways may contribute to lung cancer onset. We investigated whether the hormone status and expression of markers involved in DNA repair (BRCA1/2, ERCC1, and P53R2), synthesis (TS and RRM1), and cell division (TUBB3) might be linked to lung cancer risk.Patients and MethodsThirty-seven breast cancer survivors with unrelated lung cancer and 84 control subjects comprising women with breast cancer (42/84) or lung cancer (42/84) were enrolled. Immunohistochemistry on tumor tissue was performed. Geometric mean ratio was used to assess the association of marker levels with patient groups.ResultsEstrogen receptor was expressed in approximately 90% of the breast cancer group but was negative in the majority of the lung cancer group, a result similar to the lung cancer control group. Likewise, ER isoform β was weakly expressed in the lung cancer group. Protein analysis of breast cancer versus control had a significantly lower expression of BRCA1, P53R2, and TUBB3. Likewise, a BRCA1 reduction was observed in the lung cancer group concomitant with a BRCA2 increase. Furthermore, BRCA2 and TUBB3 increased in ipsilateral lung cancer in women who had previously received radiotherapy for breast cancer.ConclusionThe decrease of DNA-repair proteins in breast cancer could make these women more susceptible to therapy-related cancer. The increase of BRCA2 and TUBB3 in lung cancer from patients who previously received radiotherapy for breast cancer might reflect a tissue response to exposure to ionizing radiation. 相似文献
80.
Denis A. Mogilenko Oleg Shpynov Prabhakar Sairam Andhey Laura Arthur Amanda Swain Ekaterina Esaulova Simone Brioschi Irina Shchukina Martina Kerndl Monika Bambouskova Zhangting Yao Anwesha Laha Konstantin Zaitsev Samantha Burdess Susan Gillfilan Sheila A. Stewart Marco Colonna Maxim N. Artyomov 《Immunity》2021,54(1):99-115.e12